![]() ![]() Healthy brains operate with moderate levels of synchronization, while inadequate or excessive synchronization is an endophenotype in several brain disorders and contributes to the functional deficits therein 7, 8, 9. Transient, long-range synchronization of neuronal oscillations regulates neuronal processing and communication in large-scale neuronal circuits, which is essential for cognitive functions and behavior 1, 2, 3, 4, 5, 6. We suggest that the GP is fundamental for brain function allowing individual variability while retaining functional advantages of criticality. These results show that variability in synchronization levels is explained by the individual position along the GP with healthy brain areas operating in its subcritical and epileptogenic areas in its supercritical side. Synchronization and LRTCs are both positively linearly and quadratically correlated among healthy subjects, while in epileptogenic areas they are negatively linearly correlated. We analyze LRTCs and synchronization of oscillations from resting-state magnetoencephalography and stereo-electroencephalography data. We use computational modelling to assess how synchronization is dependent on brain criticality indexed by long-range temporal correlations (LRTCs). We test whether individual synchronization levels are predicted by individual brain states along an extended regime of critical-like dynamics – the Griffiths phase (GP). ![]() ![]() Yet, synchronization levels exhibit large inter-individual variability that is associated with behavioral variability. ![]() Neuronal oscillations and their synchronization between brain areas are fundamental for healthy brain function. ![]()
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